Yisimayili, Nuermaimaiti published the artcileα-Hydroxylation of α,α-Disubstituted N-tert-Butanesulfinyl Ketimines with Molecular Oxygen: Stereoselective Synthesis of α-Tertiary Hydroxyimines, Related Products of amides-buliding-blocks, the main research area is tertiary hydroxyimine preparation diastereoselective; acyclic ketimine hydroxylation.
The α-tertiary hydroxyimines (Rs/Ss,2R)-ROHC(R1)C=NS(O)t-Bu (R = butan-2-yl, cyclohex-3-en-1-yl, 1-phenylpropyl, etc.; R1 = Ph, 2-propenyl, 2-methoxyphenyl, etc.) were stereoselectively synthesized from enantioenriched N-tert-butanesulfinyl ketimines (Rs/Ss,2R)-RCH(R1)C=NS(O)t-Bu using potassium tert-butoxide, mol. oxygen, and tri-Me phosphite. The stereoselective hydroxylation of acyclic ketimines bearing two sterically similar α-substituents was achieved by controlling the geometry of the metalloenamine intermediates and the facial selectivity of hydroxylation. The synthetic utility of the resulting α-tertiary hydroxyimines was demonstrated through the successful diastereoselective synthesis of highly substituted β-amino alcs.
Organic Letters published new progress about Diastereoselective synthesis. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Related Products of amides-buliding-blocks.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics