Long, Lipeng published the artcileHypervalent iodine(III) promoted tandem reaction of o-fluoroanilines with formamides to construct 2-aminobenzoxazoles, Synthetic Route of 123-39-7, the main research area is aminobenzoxazole preparation; fluoroaniline formamide tandem reaction hypervalent iodine.
A simple and practical synthesis of 2-aminobenzoxazoles I (R = H, Br, F, etc; R1 = H, Cl, COOMe, etc; R2 = R3 = H, Et, Ph, -(CH2)2O(CH2)2-, etc; R4 = H, I, CF3, etc; R5 = Cl, Br, Me, etc;) has been developed from com. available o-fluoroanilines 2-R-3-R1-4-R4-5-R5C6(F)NH2, and formamides HC(O)N(R2)(R3). This process can be performed in the absence of metal catalysts with high levels of functional group tolerance. Hypervalent iodine(III) was both an oxidant and a Lewis acid for this reaction. A variety of substituents can be introduced into each position of the benzoxazole backbone (C-4 to C-7), providing handles for further elaboration.
Organic Chemistry Frontiers published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Synthetic Route of 123-39-7.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics