Bruffaerts, Jeffrey published the artcileFormamides as Isocyanate Surrogates: A Mechanistically Driven Approach to the Development of Atom-Efficient, Selective Catalytic Syntheses of Ureas, Carbamates, and Heterocycles, Recommanded Product: N-Methylformamide, the main research area is amine formamide ruthenium pincer complex catalyst dehydrogenative coupling DFT; urea green preparation; alc formamide ruthenium pincer complex catalyst dehydrogenative coupling DFT; carbamate green preparation; aminoalc formamide ruthenium pincer complex catalyst dehydrogenative coupling tandem; nitrogen heterocycle green preparation.
Despite the hazardous nature of isocyanates, they remain key building blocks in bulk and fine chem. synthesis. By surrogating them with less potent and readily available formamide precursors, we herein demonstrate an alternative, mechanistic approach to selectively access a broad range of ureas, carbamates, and heterocycles via ruthenium-based pincer complex catalyzed acceptorless dehydrogenative coupling reactions. The design of these highly atom-efficient procedures was driven by the identification and characterization of the relevant organometallic complexes, uniquely exhibiting the trapping of an isocyanate intermediate. D. functional theory (DFT) calculations further contributed to shed light on the remarkably orchestrated chain of catalytic events, involving metal-ligand cooperation.
Journal of the American Chemical Society published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics