Le Falher, Laetitia published the artcilePreparation of Halogen-Containing 4H-Pyrido[e][1,3]oxazin-4-ones and Their Transformation into 2-Hydroxypyridinyl-Substituted 1,2,4-Oxadiazoles and 1,2,4-Triazoles, SDS of cas: 13958-99-1, the main research area is pyridylimide sodium salt intramol arylation; pyridooxazinone halo preparation microwave irradiation hydroxylamine cyclocondensation hydrazine; oxadiazole hydroxypyridyl triazole preparation regioselective.
A complete study on the preparation of original halogen-containing 4H-pyrido[e][1,3]oxazin-4-ones I (R = C6H5, 2-H3CC6H4, 4-ClC6H4, 4-H3COC6H4, etc.; R1 = H, Br) and their transformation into 2-hydroxypyridinyl-substituted 1,2,4-oxadiazoles II (W = O) and 1,2,4-triazoles II (W = NH, NC6H5) is presented. The efficiency of the intramol. O-arylation of pyridyl-imide sodium salts e.g., III was studied on three series of compounds, with different fluoro-, chloro-, and bromophenyl substituents at the C-2 position. The final halogenated compounds I are of interest as new synthons for future functionalization. A rapid, and complementary access to 2-substituted 4H-benzo[e][1,3]oxazinones IV (R2 = 2-bromo-4-pyridyl, phenyl) were discovered. Finally, the one-step transformation of some of these pyrido-oxazinones I into the corresponding II was explored, and the regioselectivity of the reaction was proved by X-ray crystallog.
European Journal of Organic Chemistry published new progress about Acid halides Role: RCT (Reactant), RACT (Reactant or Reagent). 13958-99-1 belongs to class amides-buliding-blocks, name is 3-Bromoisonicotinamide, and the molecular formula is C6H5BrN2O, SDS of cas: 13958-99-1.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics