Ning, Yunyun published the artcileSite-specific Umpolung amidation of carboxylic acids via triplet synergistic catalysis, Quality Control of 7465-88-5, the main research area is nitroalkane carboxylic acid iridium phosphine iron catalyst Umpolung amidation; carboxylic acid nitroarene iridium phosphine iron catalyst Umpolung amidation; aralkyl amide preparation photochem.
In this paper, an Umpolung amidation reaction of carboxylic acids with nitroarenes and nitroalkanes enabled by the triplet synergistic catalysis of FeI2, P(V)/P(III) and photoredox catalysis, which avoids the production of byproducts from stoichiometric coupling reagents were disclosed. A wide range of carboxylic acids, including aliphatic, aromatic and alkenyl acids participated smoothly in such reactions, generating structurally diverse amides in good yields (86 examples, up to 97% yield). This Umpolung amidation strategy opened a method to address challenging regioselectivity issues between nucleophilic functional groups and complemented the functional group compatibility of the classical amidation protocols. The synthetic robustness of the reaction was demonstrated by late-stage modification of complex mols. and gram-scale applications.
Nature Communications published new progress about Alkanes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Quality Control of 7465-88-5.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics