Rahman, Mahbubur Md. published the artcileMetal-Free Transamidation of Secondary Amides by N-C Cleavage, Application of 4-Methoxy-N-phenylbenzamide, the main research area is secondary amide transamidation nitrogen carbon bond cleavage.
Transamidation reactions represent a fundamental chem. process involving conversion of one amide functional group into another. Herein, the authors report a facile, highly chemoselective method for transamidation of N-tert-butoxycarbonylation (N-Boc) activated secondary amides that proceeds under exceedingly mild conditions in the absence of any additives. Because this reaction was performed in the absence of metals, oxidants, or reductants, the reaction tolerates a large number of useful functionalities. The reaction is compatible with diverse amides and nucleophilic amines, affording the transamidation products in excellent yields through direct nucleophilic addition to the amide bond. The utility of this methodol. is highlighted in the synthesis of Tigan, a com. antiemetic, directly from the amide bond. The authors expect that this new metal-free transamidation will have broad implications for the development of new transformations involving direct nucleophilic addition to the amide bond as a key step.
Journal of Organic Chemistry published new progress about Amides, secondary Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Application of 4-Methoxy-N-phenylbenzamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics