Jat, Jawahar L. published the artcileMetal-free synthesis of secondary amides using N-Boc-O-tosylhydroxylamine as nitrogen source via Beckmann rearrangement, Computed Properties of 7465-88-5, the main research area is ketone tertbutyloxycarbonyl tosylhydroxylamine Beckmann rearrangement; secondary amide preparation.
Herein, the first direct method for the synthesis of secondary amides from ketones via the Beckmann rearrangement using N-Boc-O-tosylhydroxylamine (TsONHBoc) as the aminating agent was reported. This reagent was expected to play a dual role, first in the formation of the activated oxime intermediate, and then via facilitation of the amide formation as a Bronsted acid by the tosylic acid byproduct. The metal and additive-free one-step method progresses in TFE solvent through the in situ generation of the primary amine reagent (TsONH2), and produces a water-soluble byproduct.
New Journal of Chemistry published new progress about Amides, secondary Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Computed Properties of 7465-88-5.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics