Liu, Ziwei published the artcileHarnessing chemical energy for the activation and joining of prebiotic building blocks, Recommanded Product: N-Methylformamide, the main research area is nucleoside phosphate carboxylic acid catalysis dicyanoimidazole isonitrile energy ATP; prebiotic mol evolution life origin nucleoside phosphate peptide RNA; nucleotide condensation amino acid primordial phospholipid lipid.
Life is an out-of-equilibrium system sustained by a continuous supply of energy. In extant biol., the generation of the primary energy currency, ATP and its use in the synthesis of biomols. require enzymes. Before their emergence, alternative energy sources, perhaps assisted by simple catalysts, must have mediated the activation of carboxylates and phosphates for condensation reactions. Here, we show that the chem. energy inherent to isonitriles can be harnessed to activate nucleoside phosphates and carboxylic acids through catalysis by acid and 4,5-dicyanoimidazole under mild aqueous conditions. Simultaneous activation of carboxylates and phosphates provides multiple pathways for the generation of reactive intermediates, including mixed carboxylic acid-phosphoric acid anhydrides, for the synthesis of peptidyl-RNAs, peptides, RNA oligomers and primordial phospholipids. Our results indicate that unified prebiotic activation chem. could have enabled the joining of building blocks in aqueous solution from a common pool and enabled the progression of a system towards higher complexity, foreshadowing today’s encapsulated peptide-nucleic acid system.
Nature Chemistry published new progress about Carboxylic acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics