On November 30, 2015, Wang, Feng; Fan, Di; Qian, Jun; Zhang, Zhe; Zhu, Jianhua; Chen, Jian published an article.Synthetic Route of 5455-98-1 The title of the article was Preparation and Biodistribution of Technetium-99m-Labeled Bis- Misonidazole (MISO) as an Imaging Agent for Tumour Hypoxia. And the article contained the following:
Diagnosis of tumor hypoxia is an important aspect in determining the course of tumor therapy. In this study, we developed a novel imaging agent, 99mTcethylenedicysteine- bis-misonidazole (99mTc-EC-MISO), for diagnosing tumor hypoxia. We used 2-nitroimidazole as a reactant to synthesize the amino derivative of misonidazole (MISO) in the first step and then conjugated the di-amino derivative of MISO to the chelating agent ethylenedicysteine (EC) for labeling 99mTc in the second step. 99mTc-pertechnetate (99mTcO4 -) was reduced by tin chloride (SnCl2) for radiolabeling. The radiochem. purity was up to 94%. Tissue biodistribution and SPECT/CT imaging studies were conducted on s.c. gliomal tumor-bearing mice. The tumor-to-muscle ratio in the 99mTc-EC-MISO group increased with time, up to 4.6 at 4 h after injection. SPECT/CT imaging confirmed that the tumors could be visualized clearly with 99mTc-EC-MISO at 2 h. By introducing a second 2-nitroimidazole redox center, an apparent hypoxic accumulation of this novel 99mTc-labeled imaging agent in the tumor was observed The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Synthetic Route of 5455-98-1
The Article related to technetium 99m ecmiso spect ct biodistribution tumor hypoxia imaging, Placeholder for records without volume info and other aspects.Synthetic Route of 5455-98-1
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