Martin, R. Bruce; Edsall, John T.; Wetlaufer, Donald B.; Hollingworth, Barbara R. published an article in 1958, the title of the article was A complete ionization scheme for tyrosine and the ionization constants of some tyrosine derivatives.Application of 456-12-2 And the article contains the following content:
cf. preceding abstract Each of the 3 ionizing groups in the tyrosine mol. is characterized by 4 acidic constants (microconsts.) since the tendency of each group to accept or donate a proton depends upon the state of charge on the other 2 groups. Values for these 12 microconsts. were obtained for different ionic strengths, from spectrophotometric measurements at different pH values, from studies on the ionization of tyrosine derivatives, and from math. relations between the constants From the charge interactions between the NH4 and phenolic groups, a distance of 7.0 A. between the groups is calculated, by use of an ellipsoidal model of the type proposed by Kirkwood and Westheimer (C.A. 32, 82449). The distance between the carboxyl and phenolic protons was calculated to be 7.7 A. in the same manner. These values are compatible with those derived from mol. models, with the use of correct interatom. distances and bond angles. Tyrosine (10 g.) dissolved in about 300 ml. absolute MeOH with just enough 40% alc. NaOH, the mixture treated with about 30 ml. Mel, warmed in the dark, the precipitate dissolved by addition of just enough 40% alc. NaOH, the mixture held 2 hrs., cooled, filtered, the precipitate dissolved in H2O, adsorbed on Dowex 50-X8 (H), eluted with N NH4OH, evaporated to dryness, the residue in H2O adsorbed on Dowex 1-X8 (OH), eluted with 0.5N AcOH, the acetate salt evaporated to dryness, exchanged changed on Dowex 50, and the solution taken to dryness yielded N-trimethyltyrosine (I), m. approx. 260° (decomposition). pK values are reported for I, O-methyltyrosine, tyrosine Et ester, O-methyltyrosine Et ester, and tyrosinamide. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Application of 456-12-2
N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Application of 456-12-2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics