On July 5, 2021, Tirmazi, Syed Azhar Ali Shah; Qadir, Muhammad Abdul; Ahmed, Mahmood; Imran, Muhammad; Hussain, Riaz; Sharif, Mehwish; Yousaf, Muhammad; Muddassar, Muhammad published an article.Synthetic Route of 144-80-9 The title of the article was Levofloxacin and sulfa drugs linked via Schiff bases: Exploring their urease inhibition, enzyme kinetics and in silico studies. And the article contained the following:
Involvement of urease in various pathol. conditions specifically in gastric and peptic ulcers make it an important therapeutic target. In the present study urease inhibition was investigated by newly designed Schiff bases of levofloxacin. Structure elucidation of these compounds were done by spectral studies such as IR, 1H NMR and 13C NMR and elemental anal. In vitro urease enzyme inhibition assay revealed the compounds LS01, LS06 and LS07 were found to be the most potent and showed comparable IC50 values 0.58±0.11, 0.45±0.21μM and 0.52±0.28μM resp. The compound LS06 was competitive inhibitor with Ki value 1.13μM while the compounds LS01 and LS07 were mixed type of inhibitors with Ki values 3.40 and 6.03μM resp. Plausible binding mode of competitive inhibitor was predicted using mol. docking studies. Ancillary to synthetic studies, d. functional theory (DFT) at B3LYP/6-31G(d,p) basis sets in ground state is utilized in order to gain optimized geometries of LS01-LS09 mols. Different geometric parameters like mol. electrostatic potential anal., alignment of HOMO and LUMO levels, natural bonding orbital (NBO) anal. and global descriptor of reactivity were performed in support of exptl. findings. All DFT based computed results showed best agreement with exptl. finding and suggest that all synthesized compounds are chem. stable. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Synthetic Route of 144-80-9
The Article related to urease levofloxacin schiff bases enzyme kinetics inhibition, Pharmacology: Methods and other aspects.Synthetic Route of 144-80-9
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