On July 23, 2001, Meng, C. Q.; Zheng, X. S.; Holt, L. A.; Hoong, L. K.; Somers, P. K.; Hill, R. R.; Saxena, U. published an article.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide The title of the article was Nitrobenzene Compounds Inhibit Expression of VCAM-1. And the article contained the following:
A series of nitrobenzene compounds has been discovered as potent inhibitors of VCAM-1 expression and, therefore, potential drug candidates for autoimmune and allergic inflammatory diseases. Structure-activity relationship (SAR) studies showed that a nitro group and two other electron-withdrawing groups are essential for these compounds to be potent inhibitors of VCAM-1 expression. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Quality Control of 3-Nitro-4-chlorobenzenesulfonamide
The Article related to nitrobenzene compound structure activity cell adhesion mol vcam1, Pharmacology: Structure-Activity and other aspects.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics