On July 31, 2019, Liu, Renshuai; Liu, Lulu; Yang, Xinying; Fang, Hao published an article.Recommanded Product: 97-09-6 The title of the article was Discovery and development of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as Bcl-2/Mcl-1 inhibitors. And the article contained the following:
Bcl-2 family proteins play a vital role for cancer cell in escaping apoptosis, and small-mol. anti-apoptotic Bcl-2 protein inhibitors have been developed as new anticancer therapies. In current study, a series of substituted 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives were developed based on the lead compound 1 (Ki = 5.2 μM against Bcl-2 protein). The fluorescence polarization assays suggested that active compounds possessed potent binding affinities to both Bcl-2 and Mcl-1 protein, but had minor or no binding affinities to Bcl-XL protein. MTT assays showed that these compounds had certain anti-proliferative activities against cancer cells. Furthermore, it was found that active compound 11t(I) could induce cell apoptosis and caspase-3 activation in a dose-dependent manner in Jurkat cells. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Recommanded Product: 97-09-6
The Article related to neoplasm antitumor bcl2 mcl1, 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, anti-tumor, apoptosis, bcl-2, Pharmacology: Structure-Activity and other aspects.Recommanded Product: 97-09-6
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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics