On October 15, 2017, Xu, Guangsen; Liu, Tingting; Zhou, Yi; Yang, Xinying; Fang, Hao published an article.Product Details of 97-09-6 The title of the article was 1-Phenyl-1H-indole derivatives as a new class of Bcl-2/Mcl-1 dual inhibitors: Design, synthesis, and preliminary biological evaluation. And the article contained the following:
Bcl-2 proteins, such as B-cell lymphoma (Bcl-2) protein, myeloid cell leukemia sequence 1 (Mcl-1) protein, has been implicated in the progression and survival of multiple tumor types and become a validated and attractive target for cancer therapy. In this work, a series of 1-phenyl-1H-indole derivatives has been designed and synthesized. The preliminary biol. studies (binding assay for Bcl-2 proteins and MTT assay) suggested that some active compounds showed potent inhibitory activities on Bcl-2/Mcl-1 without binding on Bcl-XL. Furthermore, Compound I and II showed better anti-proliferative activity than WL-276. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Product Details of 97-09-6
The Article related to phenylindole synthesis antitumor bcl2 mcl1, 1-phenyl-1h-indole derivatives, anti-tumor, apoptosis, bcl-2/mcl-1 dual inhibition, Pharmacology: Structure-Activity and other aspects.Product Details of 97-09-6
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