On November 1, 2016, Song, Zhendong; Jin, Yue; Ge, Yang; Wang, Changyuan; Zhang, Jianbin; Tang, Zeyao; Peng, Jinyong; Liu, Kexin; Li, Yanxia; Ma, Xiaodong published an article.Safety of N-(3-Aminophenyl)acrylamide The title of the article was Synthesis and biological evaluation of azole-diphenylpyrimidine derivatives (AzDPPYs) as potent T790M mutant form of epidermal growth factor receptor inhibitors. And the article contained the following:
A series of novel azole-diphenylpyrimidine derivatives (AzDPPYs) were synthesized and biol. evaluated as potent EGFRT790M inhibitors. Among these analogs, the most active inhibitor 6e not only displayed high activity against EGFRT790M/L858R kinase (IC50 = 3.3 nM), but also was able to repress the replication of H1975 cells harboring EGFRT790M mutation at a concentration of 0.118 μmol/L. In contrast to the lead compound rociletinib, 6e slightly reduces the key EGFRT790M-induced drug resistance. Significantly, inhibitor 6e demonstrates high selectivity (SI = 299.3) for T790M-containing EGFR mutants over wild type EGFR, hinting that it will cause less side effects. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Safety of N-(3-Aminophenyl)acrylamide
The Article related to azole diphenyl pyrimidine derivative preparation egfr inhibitor cancer, azole-diphenylpyrimidine, egfr t790m, inhibitors, nsclc, synthesis, Pharmacology: Structure-Activity and other aspects.Safety of N-(3-Aminophenyl)acrylamide
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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics