On April 30, 2021, Hermann, Markus R.; Pautsch, Alexander; Grundl, Marc A.; Weber, Alexander; Tautermann, Christofer S. published an article.Related Products of 79-07-2 The title of the article was Covalent inhibitor reactivity prediction by the electrophilicity index-in and out of scope. And the article contained the following:
Drug discovery is an expensive and time-consuming process. To make this process more efficient quantum chem. methods can be employed. The electrophilicity index is one property that can be calculated by quantum chem. methods, and if calculated correctly gives insight into the reactivity of covalent inhibitors. Herein we present the usage of the electrophilicity index on three common warheads, i.e., acrylamides, 2-chloroacetamides, and propargylamides. We thoroughly examine the properties of the electrophilicity index, show which pitfalls should be avoided, and what the requirements to successfully apply the electrophilicity index are. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Related Products of 79-07-2
The Article related to acrylamide chloroacetamide propargylamide covalent inhibitor reactivity electrophilicity, compound reactivity, covalent drug discovery, dft, Physical Organic Chemistry: General and other aspects.Related Products of 79-07-2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics