Month: February 2023

Physiological role of K⁺ channels in irisin-induced vasodilation in rat thoracic aorta was written by Demirel, Sadettin;Sahinturk, Serdar;Isbil, Naciye;Ozyener, Fadil. And the article was included in Peptides (New York, NY, United States) in 2022.SDS of cas: 10238-21-8 This article mentions the following:

Irisin, an exercise-induced myokine, has been shown to have a peripheral vasodilator effect. However, little is known about the mechanisms underlying its effects. In this study, it was aimed to investigate the vasoactive effects of irisin on rat thoracic aorta, and the hypothesis that voltage-gated potassium (K_V) channels, ATP-sensitive potassium (K_ATP) channels, small-conductance calcium-activated potassium (SK_Ca) channels, large-conductance calcium-activated potassium (BK_Ca) channels, intermediate-conductance calcium-activated potassium (IK_Ca) channels, inward rectifier potassium (K_ir) channels, and two-pore domain potassium (K_2P) channels may have roles in these effects. Isometric contraction-relaxation responses of isolated thoracic aorta rings were measured with an organ bath model. The steady contraction was induced with both 10^-5 M phenylephrine and 45 mM KCl, and then the concentration-dependent responses of irisin (10^-9-10^-6 M) were examined Irisin exerted the vasorelaxant effects in both endothelium-intact and -denuded aortic rings at concentrations of 10^-8, 10^-7, and 10^-6 M (p < 0.001). Besides, K_V channel blocker 4-aminopyridine, K_ATP channel blocker glibenclamide, SK_Ca channel blocker apamin, BK_Ca channel blockers tetraethylammonium and iberiotoxin, IK_Ca channel blocker TRAM-34, and K_ir channel blocker barium chloride incubations significantly inhibited the irisin-induced relaxation responses. However, incubation of K_2P TASK-1 channel blocker anandamide did not cause a significant decrease in the relaxation responses of irisin. In conclusion, the first physiol. findings were obtained regarding the functional relaxing effects of irisin in rat thoracic aorta. Furthermore, this study is the first to report that irisin-induced relaxation responses are associated with the activity of K_V, K_ATP, SK_Ca, BK_Ca, IK_Ca, and K_ir channels. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8SDS of cas: 10238-21-8).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.SDS of cas: 10238-21-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Regioselective Bromine/Magnesium Exchange for the Selective Functionalization of Polyhalogenated Arenes and Heterocycles was written by Desaintjean, Alexandre;Haupt, Tobias;Bole, Leonie J.;Judge, Neil R.;Hevia, Eva;Knochel, Paul. And the article was included in Angewandte Chemie, International Edition in 2021.COA of Formula: C10H10F3NO2 This article mentions the following:

Using the bimetallic combination sBu₂Mg·2 LiOR (R = 2-ethylhexyl) in toluene enables efficient and regioselective Br/Mg exchanges with various dibromo-arenes and -heteroarenes under mild reaction conditions and provides bromo-substituted magnesium reagents. Assessing the role of Lewis donor additives in these reactions revealed that N,N,N’,N”,N”-pentamethyldiethylenetriamine (PMDTA) finely tunes the regioselectivity of the Br/Mg exchange on dibromo-pyridines and quinolines. Combining spectroscopic with X-ray crystallog. studies, light has been shed on the mixed Li/Mg constitution of the organometallic intermediates accomplishing these transformations. These systems reacted effectively with a broad range of electrophiles, including allyl bromides, ketones, aldehydes, and Weinreb amides in good yields. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7COA of Formula: C10H10F3NO2).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.COA of Formula: C10H10F3NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis of leprapinic acid, calycine and analogues by sequential “[3+2] cyclization/Suzuki/lactonization” reactions was written by Ahmed, Zafar;Albrecht, Uwe;Langer, Peter. And the article was included in European Journal of Organic Chemistry in 2005.HPLC of Formula: 106675-70-1 This article mentions the following:

Calycine (I) and analogs were prepared on the basis of Suzuki cross-coupling reactions of γ-alkylidene-α-hydroxybutenolides, readily available by cycloaddition of 1,3-dicarbonyl dianions or 1,3-bis(silyl enol ether)s with oxalyl derivatives, and subsequent boron tribromide-mediated lactonization. Leprapinic acid (II) was prepared by chemoselective boron tribromide-mediated deprotection of permethylated leprapinic acid. In the experiment, the researchers used many compounds, for example, N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1HPLC of Formula: 106675-70-1).

N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.HPLC of Formula: 106675-70-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis and characterization of dicyclohexylurea by the improved green methodology was written by Saurabh, Pandey;Pal, Lamba Narendra;Singh, Chauhan Manmohan;Arkaja, Goswami. And the article was included in Research Journal of Chemistry and Environment in 2022.Product Details of 2387-23-7 This article mentions the following:

The reaction of cyclohexylamine with urea under solvent-free condition is discussed. The one-step and one-pot synthesis via transamination for industrial production is studied where, cyclohexylamine is heated with urea to give desired product dicyclohexylurea (DCU) in molar yield. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Product Details of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Product Details of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Direct coupling of sp³ carbon of alkanes with α,β-unsaturated carbonyl compounds using a copper/hydroperoxide system was written by Lan, Yun;Yang, Chao;Xu, Yun-He;Loh, Teck-Peng. And the article was included in Organic Chemistry Frontiers in 2017.Product Details of 116332-61-7 This article mentions the following:

A new methodol. for the monovalent copper-initiated direct coupling of alkanes and hydroperoxides with unsaturated carbonyl compounds was developed. In this work, α,β-unsaturated carbonyl compounds underwent alkylation and peroxidation to give synthetically useful α-peroxy ketones with wide functional group tolerance. The resulting α-peroxy ketones could be easily transformed into very useful α-hydroxy ketones. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Product Details of 116332-61-7).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Product Details of 116332-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The combined effect of protein hydrolysis and Lactobacillus plantarum fermentation on antioxidant activity and metabolomic profiles of quinoa beverage was written by Meng, Fan-Bing;Zhou, Li;Li, Jia-Jia;Li, Yun-Cheng;Wang, Meng;Zou, Long-Hua;Liu, Da-Yu;Chen, Wei-Jun. And the article was included in Food Research International in 2022.SDS of cas: 53902-12-8 This article mentions the following:

Lactic acid bacteria fermentation is a commonly applied technique to produce nutritional, functional, and organoleptic enhanced foods. In the present study, protein hydrolysis and Lactobacillus plantarum fermentation were coupled to develop quinoa beverages. Protein hydrolysis effectively promoted the growth and fermentation of L. plantarum. Fermentation alone did not significantly improve antioxidant activity, but the combined use of protein hydrolysis and L. plantarum fermentation significantly improved the antioxidant activity of the quinoa beverage. Nontargeted metabolomics based on UHPLC-Q Exactive HF-X/MS and multivariate statistical anal. were performed to reveal the metabolite profile alterations of the quinoa beverage by different processing methods. A total of 756 metabolites were identified and annotated, which could be categorized into 12 different classes. The significant differentially abundant metabolites were mainly involved in primary metabolite metabolism and secondary metabolite biosynthesis. Many of these metabolites were proven to be vitally important to the function and taste formation of the quinoa beverage. Most importantly, the coupled use of protein hydrolysis and L. plantarum fermentation significantly increased some functional ingredients compared with protein hydrolysis and L. plantarum fermentation alone. The above results indicate that protein hydrolysis coupled with L. plantarum fermentation is an effective strategy to develop functional quinoa beverages. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8SDS of cas: 53902-12-8).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.SDS of cas: 53902-12-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ionic liquids/ZnO nanoparticles as recyclable catalyst for polycarbonate depolymerization was written by Iannone, Francesco;Casiello, Michele;Monopoli, Antonio;Cotugno, Pietro;Sportelli, Maria Chiara;Picca, Rosaria Anna;Cioffi, Nicola;Dell’Anna, Maria M.;Nacci, Angelo. And the article was included in Journal of Molecular Catalysis A: Chemical in 2017.Computed Properties of C13H24N2O This article mentions the following:

A useful protocol for waste bis-phenol A-polycarbonates (BPA-PC) chem. recycling is proposed based on a bifunctional acid/basic catalyst composed by nanostructured zinc oxide and tetrabutylammonium chloride (ZnO-NPs/NBu₄Cl) in quality of Lewis acid and base, resp. Retro-polymerization reaction proved to be of general application for several nucleophiles, including water, alcs., amines, polyols, aminols and polyamines, leading to the complete recovery of BPA monomer and enabling the PC polymer to function as a green carbonylating agent (green phosgene alternative) for preparing carbonates, urethanes and ureas. A complete depolymerization can be obtained in seven hours at 100 °C and ZnO nanocatalyst can be recycled several times without sensible loss of activity. Remarkably, when polycarbonate is reacted with glycerol, it is possible to realize in a single process the conversion of two industrial wastes (BPA-PC and glycerol) into two valuable chems. like BPA monomer and glycerol carbonate (the latter being a useful industrial solvent and fuel additive). In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Computed Properties of C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Computed Properties of C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rhodium(III)-catalyzed Oxidative Coupling of N-Methoxybenzamides and Ethenesulfonyl fluoride: a C-H Bond Activation Strategy for the Preparation of 2-Aryl ethenesulfonyl fluorides and Sulfonyl fluoride Substituted γ-Lactams was written by Wang, Shi-Meng;Li, Chen;Leng, Jing;Bukhari, Syed Nasir Abbas;Qin, Hua-Li. And the article was included in Organic Chemistry Frontiers in 2018.SDS of cas: 192436-83-2 This article mentions the following:

A method for the synthesis of 2-aryl ethenesulfonyl fluorides such as I [R = 4-Me, 4-OMe, 5-Ph, etc.] and sulfonyl fluoride substituted γ-lactams II [R = 4-Me, 4-OMe, 6-Ph, etc.] was developed through a rhodium(III)-catalyzed oxidative coupling of N-methoxybenzamides and ethenesulfonyl fluoride in moderate to excellent yields. This protocol featured an exclusive E-stereo selectivity and a monoselective ortho activation of sp² C-H bonds of the benzene rings. This research revealed that the much less reactive Heck coupling partner ethenesulfonyl fluoride possesses the feasibility for coupling with sp² C-H bonds to provide a class of new sulfonyl fluoride scaffolds for the SuFEx click reaction. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2SDS of cas: 192436-83-2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.SDS of cas: 192436-83-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

¹⁹F-{¹H} NMR study of exchange equilibriums with participation of sulfonamides and their phenylmercuric derivatives in DMSO was written by Kravtsov, D. N.;Peregudov, A. S.;Ivanov, V. F.. And the article was included in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1983.Name: N-Isopropylbenzenesulfonamide This article mentions the following:

Equil constants (K) were determined for exchange of the PhHg group between 4-PhSO₂N(HgPh)C₆H₄R (I; R = H, F) and PhSO₂NHR¹ (II; R¹ = alkyl, Ph, substituted phenyl). The following relation was obtained for exchanges between I (R = H) and II (R¹ = m– and p-substituted phenyl): log K = -0.27 pK_a + 3.46. Deviation from this equation were found for II with steric and intramol. coordination interactions. In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5Name: N-Isopropylbenzenesulfonamide).

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Name: N-Isopropylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sodium perborate bleaching of cotton by using tetraacetyl ethylenediamine activator was written by Indi, Yashovardhan Mallikarjun;Wasif, Akhilahmad. And the article was included in Indian Journal of Fibre & Textile Research in 2018.Recommanded Product: 10543-57-4 This article mentions the following:

In the present work, attempt has been made to bleach the scoured cotton fabric with sodium perborate as bleaching agent and tetraacetyl ethylenediamine as bleach activator. The concentrations of these chems., temperature and time of the treatment have been varied. When sodium perborate comes in contact with water in bleaching bath, it releases hydrogen peroxide which is responsible for bleaching action on cotton. The findings of this novel process on the quality of bleached fabric are compared with the fabric bleached conventionally using only hydrogen peroxide. The results show that the utilization of generated hydrogen peroxide reaches as high as 96% in the modified bleaching process, which is only 70% in the case of conventional bleaching. Further, the modified bleaching process requires less water and energy, thus fulfilling the requirements of ecofriendly process. Loss in weight, tearing strength and tensile strength are found less comparing to conventional bleaching without compromising with whiteness index. CIE whiteness with conventional bleaching is 57, whereas modified recipe shows 61 whiteness. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Recommanded Product: 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Recommanded Product: 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics