Month: February 2023

A facile synthesis of 2,3-disubstituted furo[2,3-b]pyridines was written by Beutner, Gregory L.;Kuethe, Jeffrey T.;Yasuda, Nobuyoshi. And the article was included in Tetrahedron Letters in 2009.Related Products of 116332-61-7 This article mentions the following:

In a three-step sequence starting from readily available starting materials, 2,3-carbon disubstituted furo[2,3-b]pyridines can be accessed in good yields and purity. Furo[2,3-b]pyridines bearing ester, amide and ketone groups at the 2-position can be prepared with a variety of aryl and alkyl groups at the 3-position. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Related Products of 116332-61-7).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Related Products of 116332-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Glibenclamide alleviates beta adrenergic receptor activation-induced cardiac inflammation was written by Cao, Ning;Wang, Jing-jing;Wu, Ji-min;Xu, Wen-li;Wang, Rui;Chen, Xian-da;Feng, Ye-nan;Cong, Wen-wen;Zhang, You-yi;Xiao, Han;Dong, Er-dan. And the article was included in Acta Pharmacologica Sinica in 2022.Recommanded Product: 10238-21-8 This article mentions the following:

Aβ-Adrenergic receptor (β-AR) overactivation is a major pathol. factor associated with cardiac diseases and mediates cardiac inflammatory injury. Glibenclamide has shown anti-inflammatory effects in previous research. However, it is unclear whether and how glibenclamide can alleviate cardiac inflammatory injury induced by β-AR overactivation. In the present study, male C57BL/6J mice were treated with or without the β-AR agonist isoprenaline (ISO) with or without glibenclamide pretreatment. The results indicated that glibenclamide alleviated ISO-induced macrophage infiltration in the heart, as determined by Mac-3 staining. Consistent with this finding, glibenclamide also inhibited ISO-induced chemokines and proinflammatory cytokines expression in the heart. Moreover, glibenclamide inhibited ISO-induced cardiac fibrosis and dysfunction in mice. To reveal the protective mechanism of glibenclamide, the NLRP3 inflammasome was further analyzed. ISO activated the NLRP3 inflammasome in both cardiomyocytes and mouse hearts, but this effect was alleviated by glibenclamide pretreatment. Furthermore, in cardiomyocytes, ISO increased the efflux of potassium and the generation of ROS, which are recognized as activators of the NLRP3 inflammasome. The ISO-induced increases in these processes were inhibited by glibenclamide pretreatment. Moreover, glibenclamide inhibited the cAMP/PKA signalling pathway, which is downstream of β-AR, by increasing phosphodiesterase activity in mouse hearts and cardiomyocytes. In conclusion, glibenclamide alleviates β-AR overactivation-induced cardiac inflammation by inhibiting the NLRP3 inflammasome. The underlying mechanism involves glibenclamide-mediated suppression of potassium efflux and ROS generation by inhibiting the cAMP/PKA pathway. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Recommanded Product: 10238-21-8).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Recommanded Product: 10238-21-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Novel Metal-Organic Framework (MOF) Based Composite Material for the Sequestration of U(VI) and Th(IV) Metal Ions from Aqueous Environment was written by Alqadami, Ayoub Abdullah;Naushad, Mu.;Alothman, Zeid Abdullah;Ghfar, Ayman A.. And the article was included in ACS Applied Materials & Interfaces in 2017.Computed Properties of C13H24N2O This article mentions the following:

The combination of magnetic nanoparticles and metal-organic frameworks (MOFs) has demonstrated their prospective for pollutant sequestration. In this work, a magnetic metal-organic framework nanocomposite (Fe₃O₄@AMCA-MIL53(Al)) was prepared and used for the removal of U(VI) and Th(IV) metal ions from aqueous environment. Fe₃O₄@AMCA-MIL53(Al) nanocomposite was characterized by TGA, FTIR, SEM-EDX, XRD, HRTEM, BET, VSM (vibrating sample magnetometry), and XPS analyses. A batch technique was applied for the removal of the aforesaid metal ions using Fe₃O₄@AMCA-MIL53(Al) at different operating parameters. The isotherm and kinetic data were accurately described by the Langmuir and pseudo-second-order models. The adsorption capacity was calculated to be 227.3 and 285.7 mg/g for U(VI) and Th(IV), resp., by fitting the equilibrium data to the Langmuir model. The kinetic studies demonstrated that the equilibrium time was 90 min for each metal ion. Various thermodn. parameters were evaluated which indicated the endothermic and spontaneous nature of adsorption. The collected outcomes showed that Fe₃O₄@AMCA-MIL53(Al) was a good material for the exclusion of these metal ions from aqueous medium. The adsorbed metals were easily recovered by desorption in 0.01 M HCl. The excellent adsorption capacity and the response to the magnetic field made this novel material an auspicious candidate for environmental remediation technologies. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Computed Properties of C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Computed Properties of C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Triphenylamine and Triphenylaminecarboxylic Acid was written by Goldberg, Irma;Nimerovsky, Marie. And the article was included in Berichte der Deutschen Chemischen Gesellschaft in 1907.Name: N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide This article mentions the following:

Triphenylamine-o-carboxylic acid, Ph₂NC₆H₄CO₂H, from phenylanthranilic acid, iodobenzene, potassium carbonate and a little copper, in nitrobenzene solution, at 200-215°. The yield is increased to 94% of the theory and the product is purer by the use of 3-4 mol. of iodobenzene. Sulphur-colored, icathery crystals, m. 208° (corr.). Concentrated sulphuric acid dissolves it with a blue color, changing to deep green with a little nitric acid; on heating the colors are yellow and blood red, respectively. N-Phenylacridone,C₆H₄ C₆H₄, by the action of concentrated sulphuric acid on the preceding compound, at 100°. Large, lustrous, sulphur-colored crystals, m. 276° (corr.). The yield is 86% of the theoretical. The glacial acetic acid solution has an intense blue fluorescence, which becomes green in concentrated sulphuric acid, the color of the solution being yellow. Nitric acid destroys the fluorescence, which is not exhibited by the acridone in amyl alcohol solution. On heating the above carboxylic acid over 200°, for a short time, it is converted, practically quantitatively, into triphenylamine, m. 125°, which is also prepared without difficulty, from diphenylamine, iodobenzene, potassium carbonate and a little copper, in presence of nitrobenzene. Concentrated sulphuric acid gives a green solution with a blue fluorescence; the addition of a little nitric acid increases the intensity of the green color; water precipitates colorless flocks. N-p-Tolylphenylanthranilic acid. MeC₆H₄NPhC₆H₄CO₂H, from p-iodotoluene, in amyl alcoholic solution, at 160-170°. Pale yellow, crystalline powder, m. 175° (corr.), yield 82% of the theory. Concentrated sulphuric acid gives a dark blue solution, changing to green on the addition of nitric acid. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Name: N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Name: N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3) was written by Smith, D. G.;Buffet, M.;Fenwick, A. E.;Haigh, D.;Ife, R. J.;Saunders, M.;Slingsby, B. P.;Stacey, R.;Ward, R. W.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2001.Quality Control of 2-(2-Chlorophenyl)acetamide This article mentions the following:

Potent 3-anilino-4-arylmaleimide glycogen synthase kinase-3 (GSK-3) inhibitors have been prepared using automated array methodol. A number of these are highly selective, having little inhibitory potency against more than 20 other protein kinases. In the experiment, the researchers used many compounds, for example, 2-(2-Chlorophenyl)acetamide (cas: 10268-06-1Quality Control of 2-(2-Chlorophenyl)acetamide).

2-(2-Chlorophenyl)acetamide (cas: 10268-06-1) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Quality Control of 2-(2-Chlorophenyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The effect of methotrexate on experimental salivary gland neoplasia in rats was written by Shklar, G.;Sonis, S. T.. And the article was included in Archives of Oral Biology in 1975.Reference of 7413-34-5 This article mentions the following:

Na methotrexate (I) [7413-34-5] (0.1 or 1.0 mg, s.c., twice weekly) accelerated carcinogenesis induced by implantation of 9,10-dimethyl-1,2-benzanthracene (II) pellets into the right submandibular gland of rats. After 12 weeks the carcinomas in I and II-treated rats were considerably larger than those in II-treated animals and there was greater invasiveness into the glandular tissue. In the experiment, the researchers used many compounds, for example, Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5Reference of 7413-34-5).

Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Reference of 7413-34-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Utility of a novel turn-off fluorescence probe for the determination of tranilast, an adjunctive drug for patients with severe COVID-19 was written by Dagher, Diaa;Elmansi, Heba;Nasr, Jenny Jeehan;El-Enany, Nahed. And the article was included in RSC Advances in 2022.Formula: C18H17NO5 This article mentions the following:

Tranilast (TR) could be investigated as a suitable anti-inflammatory and NLRP3 inflammasome inhibitor medication for the treatment of COVID-19 acute patients. Owing to its importance, our study was constructed for the determination of TR using a new, fast, sensitive, and reliable green spectrofluorimetric method. TR was quantified in this study by forming a complex with the acriflavine (AC) reagent. The reaction between TR and AC quenched the fluorescence of AC through the formation of an ion-association complex and the response was measured at 493 nm after excitation at 263 nm. It was observed that the quenching of the fluorescence of AC was linear (r = 0.9998) with the concentration of TR in the range of 1.0-15.0 μg mL-1. The limit of detection was 0.224 μg mL-1, and the limit of quantification was 0.679 μg mL-1. The fluorescence quenching mechanism was carefully studied and was confirmed to be able to analyze TR in its pure form and its prepared pharmaceutical dosage form. To validate the method, the international conference of harmonization (ICH) Q2R1 guidelines were followed. The statistical assessment of the proposed and comparison methods revealed no significant differences between them. Moreover, the green criteria of the method were evaluated and confirmed. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Formula: C18H17NO5).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Formula: C18H17NO5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Evaluation of antioxidant, antidiabetic and antihyperlipidaemic activity of methanolic extract of Casearia elliptica in alloxan induced male wistar diabetic rats was written by Tarun, Mudadla;Praveen, Vataka;Ramani, Seemusiri Usha;Devi, Yeddu Iswarya;Madhu, Chandaka. And the article was included in Indo American Journal of Pharmaceutical Sciences in 2022.SDS of cas: 10238-21-8 This article mentions the following:

Background: Diabetes mellitus is a group of metabolic disorders with the common manifestations, hyperglycemia. Alloxan causes a massive reduction in insulin release by the destruction of β cells of the islets of langerhans, there by inducing hyperglycemia. Alloxan has been shown to induce free radical production and cause tissue injury. The aim of the present investigation was to evaluate the antioxidant, antihyperlipidemic and antidiabetic activity of methanolic extract taken from Casearia elliptica. Methods: The methanolic extract of Casearia elliptica whole plant used for the study. The Phytochem. test, acute toxicity study and oral glucose test was performed. Diabetes was induced in rat by single intra-peritoneal injection of alloxan (120 mg/kg). Male albino Wistar rats were divided into five groups each consisting of six animals as follows:Group I- Administered vehicle serves as Normal control.,Group II- Administered Alloxan (120 mg/kg s.c.) serves as diabetic control,Group III- Administered Reference Standard, (Glibenclamide 10 mg/kg, orally once daily),Group IV- Diabetic rats treated with Casearia elliptica (250mg/kg b.wt), serves as treated group,Group V- Diabetic rats treated with Casearia elliptica (500mg/kg b.wt), serves as treated group. Bodyweight of each rat in the different groups was recorded daily. Biochem. and antioxidant enzyme parameters were determined on day 14. Histol. of different organ (heart, liver, kidney, and pancreas) was performed after sacrificing the rats with euthanasia. Results: Preliminary Phytochem. investigation of methanolic extracts of whole plant of Casearia elliptica was carried out and found that it contains fixed oil, saponins, alkaloids and carbohydrates. The maximum tolerated dose of root of Casearia elliptica was found as 2000 mg/kg after completion of toxicity study according to OECD guideline. The methanolic extract of whole plant of Casearia elliptica has potential anti-diabetic action in alloxan induced diabetic rats and the effect was found equally effective with glibenclamide at higher dose. Our study clearly reveals that MECE has some obvious therapeutic implications in treating hyperglycemia, atherogenic lipoprotein profile and also possess antioxidant activity. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8SDS of cas: 10238-21-8).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.SDS of cas: 10238-21-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Effect of Reactive Distillation on the Yield of Tetraacetylethylenediamine (TAED) was written by Kim, Eun-Seon;Park, Kyun Young;Heo, Jung-Moo;Kim, Byung Jo;Ahn, Kyo Duck;Lee, Jong-Gi. And the article was included in Industrial & Engineering Chemistry Research in 2010.Product Details of 10543-57-4 This article mentions the following:

Tetraacetylethylenediamine (TAED) was prepared by acetylation of diacetylethylenediamine (DAED) with acetic anhydride in a 5 L reactor coupled with a packed distillation column, 2.5 cm in inside diameter and 1 m in length. The reaction temperature was set at 135 °C and the reflux ratio at 6. The molar ratio of acetic anhydride to DAED was varied from 3 to 5. A TAED yield as high as 80% was obtained, higher by 15% than in the absence of distillation The temporal variation of the TAED yield was calculated using the kinetic parameters in the literature. Calculated and exptl. values showed good agreement. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Product Details of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Product Details of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tranilast-delivery surgical sutures to ameliorate wound healing by reducing scar formation through regulation of TGF-β expression and fibroblast recruitment was written by Choi, Sung Yoon;Kim, Byung Hwi;Huh, Beom Kang;Jeong, Woong;Park, Min;Park, Hyo Jin;Park, Ji-Ho;Heo, Chan Yeong;Choy, Young Bin. And the article was included in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2018.Electric Literature of C18H17NO5 This article mentions the following:

We describe surgical sutures enabled with the local, sustained delivery of a TGF-β inhibitory drug, tranilast. To fabricate drug-delivery sutures, we sep. prepared a tranilast-loaded strand using poly(lactic-co-glycolic acid), which was then phys. braided with a surgical suture already in clin. use. By this method, the drug-delivery sutures maintained the mech. strength and allowed the modulation of drug release profiles by simply altering the tranilast-loaded strand. The drug-delivery sutures herein released tranilast for up to 14 days. When applied to animal models, scarring was indeed reduced with diminished TGF-β expression and fibroblast numbers during the entire 21 day testing period. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Electric Literature of C18H17NO5).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Electric Literature of C18H17NO5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics