February 2023 - Page 21 of 29 - Amides-buliding-blocks

Zhang, Jing et al. published their research in Applied Biochemistry and Biotechnology in 2022 | CAS: 10238-21-8

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Quality Control of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide

Antidiabetic Potential of Sinigrin Against Streptozotocin-Induced Diabetes via Modulating Inflammation and Oxidative Stress was written by Zhang, Jing;Wang, Shuling. And the article was included in Applied Biochemistry and Biotechnology in 2022.Quality Control of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide This article mentions the following:

Diabetes mellitus (DM) is a common metabolic disorder which arises due to the improper carbohydrate metabolism, decreased secretion/activity of insulin, and genetic abnormalities, which result in the increased blood glucose level generally known as hyperglycemia. Diabetes holds an increased global prevalence in each year and is responsible for increased morbidity and mortality rates. Hence, the current investigation focusses to assess the antidiabetic potential of sinigrin on diabetic animal model through the suppression of inflammation. Diabetes was initiated to the animals via administering streptozotocin (STZ) and supplemented with the sinigrin at 25- and 50-mg/kg dose via oral route. The diabetic rats demonstrated the elevated glucose, food and water intake, kidney and liver weights, and reduced bodyweight and depleted insulin status. The sinigrin treatment remarkably improved and modulated these changes in diabetic animals. Addnl., the sinigrin supplementation also modulated the changes in glucose-6-phosphatase; fructose 1,6-bisphosphatase; AST; ALT; creatinine; and inflammatory mediators in the STZ-provoked diabetic animals. The levels of hexokinase, protein, and antioxidants also improved by the sinigrin treatment. The histol. investigations of pancreas also witnessed the therapeutic actions of sinigrin, which is supported by the findings of biochem. examinations Therefore, it was clear that the sinigrin supplementation displayed remarkable antidiabetic effect on STZ-initiated diabetic animals via modulating inflammation and other biochem. changes, which recommends that sinigrin could be a talented candidate for diabetes management in the future. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Quality Control of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide).

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Besserer, Kurt et al. published their research in Z Zagadnien Nauk Sadowych in 2000 | CAS: 19311-91-2

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Recommanded Product: N,N-Diethylsalicylamide

Salicylamide in urine after intake of acetylsalicylic acid due to degradation of salicylic acid conjugates was written by Besserer, Kurt;Tiess, Detlef;Kala, Maria. And the article was included in Z Zagadnien Nauk Sadowych in 2000.Recommanded Product: N,N-Diethylsalicylamide This article mentions the following:

In addition to the well-known acetylsalicylic acid metabolites, salicylamide (SA) was detected in urine from healthy persons after intake of acetylsalicylic acid. SA was found in the Et₂O extracts of urine after alkalinization by ammonia solution SA was identified by gas chromatog.-mass spectrometry. Further examination showed that SA was present in urine only after alkalinization by ammonia solution and not after alkalinization by NaHCO₃ or Na₂CO₃. When dimethyl-, diethyl- or dibutylamine was used for the alkalinization of the urine, the corresponding salicylic acid dialkylamides were detected. Further anal. led to the conclusion that ester-type salicylic acid glucuronide conjugates undergo degradation by hydrolytic amination to form the corresponding amides. This gives the possibility of a specific demonstration of the presence of ester-type glucuronide conjugates. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Recommanded Product: N,N-Diethylsalicylamide).

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lynch, Christopher L. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2002 | CAS: 106675-70-1

N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Computed Properties of C6H12N2O4

1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: Synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV was written by Lynch, Christopher L.;Hale, Jeffrey J.;Budhu, Richard J.;Gentry, Amy L.;Mills, Sander G.;Chapman, Kevin T.;MacCoss, Malcolm;Malkowitz, Lorraine;Springer, Martin S.;Gould, Sandra L.;DeMartino, Julie A.;Siciliano, Salvatore J.;Cascieri, Margaret A.;Carella, Anthony;Carver, Gwen;Holmes, Karen;Schleif, William A.;Danzeisen, Renee;Hazuda, Daria;Kessler, Joseph;Lineberger, Janet;Miller, Michael;Emini, Emilio A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2002.Computed Properties of C6H12N2O4 This article mentions the following:

A series of α-(pyrrolidin-1-yl)acetic acids I [R¹ = H, Me, Me₂CH, cyclopropyl, cyclobutylmethyl, cyclohexyl, Ph, etc.; R² = Ph(CH₂)₃, 4-FC₆H₄; R³ = H, HO] was prepared and investigated as selective and potent antivirals against HIV. Several of the pyrrolidine zwitterions demonstrated reasonable in vitro properties, enhanced antiviral activities and improved pharmacokinetic profiles over the lead pyrrolidine. In the experiment, the researchers used many compounds, for example, N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1Computed Properties of C6H12N2O4).

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tavccer, Petra Forte et al. published their research in Biocatalysis and Biotransformation in 2012 | CAS: 10543-57-4

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Computed Properties of C10H16N2O4

Low-temperature bleaching of cotton induced by glucose oxidase enzymes and hydrogen peroxide activators was written by Tavccer, Petra Forte. And the article was included in Biocatalysis and Biotransformation in 2012.Computed Properties of C10H16N2O4 This article mentions the following:

Glucose oxidase enzymes were used to produce hydrogen peroxide from glucose and oxygen in aqueous solutions Different working conditions, i.e., temperature, aeration with liquefied air, presence of cotton fiber and time of enzyme activity, were tested in order to obtain a solution with the highest possible concentration of hydrogen peroxide. The hydrogen peroxide produced was transformed into different peracids which could bleach the cotton fabric under mild conditions, at a pH between 7 and 8 and at a temperature of around 60°C. The conversion or activation of hydrogen peroxide was conducted with the bleach activators TAED, NOBS and TBBC. The concentrations of hydrogen peroxide and peracids in the solutions were measured with sodium thiosulfate titrations The results indicated that the formation of hydrogen peroxide with glucose oxidase was effective under optimal conditions, which are 50°C, pH 4.6 and aeration. Convenient activators for the conversion of hydrogen peroxide into peracids were TAED and TBBC, which enabled attainment of a relatively high degree of whiteness at pH 7.5 and temperature 50°C. Using the activator NOBS under these conditions did not provide enough peracid to markedly improve whiteness. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Computed Properties of C10H16N2O4).

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Peiyi et al. published their research in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2012 | CAS: 10543-57-4

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Application In Synthesis of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)

Reinforcement of hydrogen peroxide bleaching of bamboo pulp was written by Li, Peiyi;Zhang, Meiyun;Xia, Xinxing;Lin, Chuntao. And the article was included in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2012.Application In Synthesis of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) This article mentions the following:

Magnesium-based alkalis and the Chelants (tetra acetyl ethylene diamine (TAED), Sodium Citrate and Opal) for hydrogen peroxide bleaching of bamboo pulp were investigated in this paper. The results showed that the optimal conditions of hydrogen peroxide bleaching of bamboo pulp were as follows: H₂O₂ 4%, Mg(OH)₂:NaOH=25%, Sodium Citrate 1%, Opal 1.5%, TAED:H₂O₂=0.67, temperature 60°C, and time 90 min. Under the optimum conditions, the brightness of bamboo pulp can be enhanced from 41.2% ISO to 78.2% ISO, while the brightness of bleached pulp by using the Mg(OH)₂-based alkalis was higher than by using NaOH as the alkali source. It can be seen that Sodium Citrate, Opal, and TAED activated H₂O₂ bleaching needed lower reaction temperature, shorter time, and got better brightness and alleviated environment pollution, compared with the conventional H₂O₂ bleaching of the same pulp. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Application In Synthesis of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)).

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ochi, Kosuke et al. published their research in Cancer Science in 2022 | CAS: 53902-12-8

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Synthetic Route of C18H17NO5

Drug repositioning of tranilast to sensitize a cancer therapy by targeting cancer-associated fibroblast was written by Ochi, Kosuke;Suzawa, Ken;Thu, Yin Min;Takatsu, Fumiaki;Tsudaka, Shimpei;Zhu, Yidan;Nakata, Kentaro;Takeda, Tatsuaki;Shien, Kazuhiko;Yamamoto, Hiromasa;Okazaki, Mikio;Sugimoto, Seiichiro;Shien, Tadahiko;Okamoto, Yoshiharu;Tomida, Shuta;Toyooka, Shinichi. And the article was included in Cancer Science in 2022.Synthetic Route of C18H17NO5 This article mentions the following:

Cancer-associated fibroblasts (CAFs) are a major component of the tumor microenvironment that mediate resistance of cancer cells to anticancer drugs. Tranilast is an antiallergic drug that suppresses the release of cytokines from various inflammatory cells. In this study, we investigated the inhibitory effect of tranilast on the interactions between non-small cell lung cancer (NSCLC) cells and the CAFs in the tumor microenvironment. Three EGFR-mutant NSCLC cell lines, two KRAS-mutant cell lines, and three CAFs derived from NSCLC patients were used. To mimic the tumor microenvironment, the NSCLC cells were cocultured with the CAFs in vitro, and the mol. profiles and sensitivity to mol. targeted therapy were assessed. Crosstalk between NSCLC cells and CAFs induced multiple biol. effects on the NSCLC cells both in vivo and in vitro, including activation of the STAT3 signaling pathway, promotion of xenograft tumor growth, induction of epithelial-mesenchymal transition (EMT), and acquisition of resistance to mol.-targeted therapy, including EGFR-mutant NSCLC cells to osimertinib and of KRAS-mutant NSCLC cells to selumetinib. Treatment with tranilast led to inhibition of IL-6 secretion from the CAFs, which, in turn, resulted in inhibition of CAF-induced phospho-STAT3 upregulation. Tranilast also inhibited CAF-induced EMT in the NSCLC cells. Finally, combined administration of tranilast with mol.-targeted therapy reversed the CAF-mediated resistance of the NSCLC cells to the mol.-targeted drugs, both in vitro and in vivo. Our results showed that combined administration of tranilast with mol.-targeted therapy is a possible new treatment strategy to overcome drug resistance caused by cancer-CAF interaction. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Synthetic Route of C18H17NO5).

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dagher, Diaa et al. published their research in RSC Advances in 2022 | CAS: 53902-12-8

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Formula: C18H17NO5

Utility of a novel turn-off fluorescence probe for the determination of tranilast, an adjunctive drug for patients with severe COVID-19 was written by Dagher, Diaa;Elmansi, Heba;Nasr, Jenny Jeehan;El-Enany, Nahed. And the article was included in RSC Advances in 2022.Formula: C18H17NO5 This article mentions the following:

Tranilast (TR) could be investigated as a suitable anti-inflammatory and NLRP3 inflammasome inhibitor medication for the treatment of COVID-19 acute patients. Owing to its importance, our study was constructed for the determination of TR using a new, fast, sensitive, and reliable green spectrofluorimetric method. TR was quantified in this study by forming a complex with the acriflavine (AC) reagent. The reaction between TR and AC quenched the fluorescence of AC through the formation of an ion-association complex and the response was measured at 493 nm after excitation at 263 nm. It was observed that the quenching of the fluorescence of AC was linear (r = 0.9998) with the concentration of TR in the range of 1.0-15.0 μg mL-1. The limit of detection was 0.224 μg mL-1, and the limit of quantification was 0.679 μg mL-1. The fluorescence quenching mechanism was carefully studied and was confirmed to be able to analyze TR in its pure form and its prepared pharmaceutical dosage form. To validate the method, the international conference of harmonization (ICH) Q2R1 guidelines were followed. The statistical assessment of the proposed and comparison methods revealed no significant differences between them. Moreover, the green criteria of the method were evaluated and confirmed. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Formula: C18H17NO5).

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tarun, Mudadla et al. published their research in Indo American Journal of Pharmaceutical Sciences in 2022 | CAS: 10238-21-8

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.SDS of cas: 10238-21-8

Evaluation of antioxidant, antidiabetic and antihyperlipidaemic activity of methanolic extract of Casearia elliptica in alloxan induced male wistar diabetic rats was written by Tarun, Mudadla;Praveen, Vataka;Ramani, Seemusiri Usha;Devi, Yeddu Iswarya;Madhu, Chandaka. And the article was included in Indo American Journal of Pharmaceutical Sciences in 2022.SDS of cas: 10238-21-8 This article mentions the following:

Background: Diabetes mellitus is a group of metabolic disorders with the common manifestations, hyperglycemia. Alloxan causes a massive reduction in insulin release by the destruction of β cells of the islets of langerhans, there by inducing hyperglycemia. Alloxan has been shown to induce free radical production and cause tissue injury. The aim of the present investigation was to evaluate the antioxidant, antihyperlipidemic and antidiabetic activity of methanolic extract taken from Casearia elliptica. Methods: The methanolic extract of Casearia elliptica whole plant used for the study. The Phytochem. test, acute toxicity study and oral glucose test was performed. Diabetes was induced in rat by single intra-peritoneal injection of alloxan (120 mg/kg). Male albino Wistar rats were divided into five groups each consisting of six animals as follows:Group I- Administered vehicle serves as Normal control.,Group II- Administered Alloxan (120 mg/kg s.c.) serves as diabetic control,Group III- Administered Reference Standard, (Glibenclamide 10 mg/kg, orally once daily),Group IV- Diabetic rats treated with Casearia elliptica (250mg/kg b.wt), serves as treated group,Group V- Diabetic rats treated with Casearia elliptica (500mg/kg b.wt), serves as treated group. Bodyweight of each rat in the different groups was recorded daily. Biochem. and antioxidant enzyme parameters were determined on day 14. Histol. of different organ (heart, liver, kidney, and pancreas) was performed after sacrificing the rats with euthanasia. Results: Preliminary Phytochem. investigation of methanolic extracts of whole plant of Casearia elliptica was carried out and found that it contains fixed oil, saponins, alkaloids and carbohydrates. The maximum tolerated dose of root of Casearia elliptica was found as 2000 mg/kg after completion of toxicity study according to OECD guideline. The methanolic extract of whole plant of Casearia elliptica has potential anti-diabetic action in alloxan induced diabetic rats and the effect was found equally effective with glibenclamide at higher dose. Our study clearly reveals that MECE has some obvious therapeutic implications in treating hyperglycemia, atherogenic lipoprotein profile and also possess antioxidant activity. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8SDS of cas: 10238-21-8).

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kim, Eun-Seon et al. published their research in Industrial & Engineering Chemistry Research in 2010 | CAS: 10543-57-4

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Product Details of 10543-57-4

Effect of Reactive Distillation on the Yield of Tetraacetylethylenediamine (TAED) was written by Kim, Eun-Seon;Park, Kyun Young;Heo, Jung-Moo;Kim, Byung Jo;Ahn, Kyo Duck;Lee, Jong-Gi. And the article was included in Industrial & Engineering Chemistry Research in 2010.Product Details of 10543-57-4 This article mentions the following:

Tetraacetylethylenediamine (TAED) was prepared by acetylation of diacetylethylenediamine (DAED) with acetic anhydride in a 5 L reactor coupled with a packed distillation column, 2.5 cm in inside diameter and 1 m in length. The reaction temperature was set at 135 °C and the reflux ratio at 6. The molar ratio of acetic anhydride to DAED was varied from 3 to 5. A TAED yield as high as 80% was obtained, higher by 15% than in the absence of distillation The temporal variation of the TAED yield was calculated using the kinetic parameters in the literature. Calculated and exptl. values showed good agreement. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Product Details of 10543-57-4).

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Choi, Sung Yoon et al. published their research in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2018 | CAS: 53902-12-8

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Electric Literature of C18H17NO5

Tranilast-delivery surgical sutures to ameliorate wound healing by reducing scar formation through regulation of TGF-β expression and fibroblast recruitment was written by Choi, Sung Yoon;Kim, Byung Hwi;Huh, Beom Kang;Jeong, Woong;Park, Min;Park, Hyo Jin;Park, Ji-Ho;Heo, Chan Yeong;Choy, Young Bin. And the article was included in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2018.Electric Literature of C18H17NO5 This article mentions the following:

We describe surgical sutures enabled with the local, sustained delivery of a TGF-β inhibitory drug, tranilast. To fabricate drug-delivery sutures, we sep. prepared a tranilast-loaded strand using poly(lactic-co-glycolic acid), which was then phys. braided with a surgical suture already in clin. use. By this method, the drug-delivery sutures maintained the mech. strength and allowed the modulation of drug release profiles by simply altering the tranilast-loaded strand. The drug-delivery sutures herein released tranilast for up to 14 days. When applied to animal models, scarring was indeed reduced with diminished TGF-β expression and fibroblast numbers during the entire 21 day testing period. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Electric Literature of C18H17NO5).

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics