Study on mutagenicity of daunomycin and methotrexate sodium by Ames test and SCE method was written by Zhao, Shou-Yun;Chiu, Hsin-Fang;Li, Chang-Pen;Chin, Shih-Chen;Fu, Shao-Min. And the article was included in Yichuan in 1981.Related Products of 7413-34-5 This article mentions the following:
Daunomycin (I) [20830-81-3] induced mutagenesis in histidine-deficient strains of Salmonella typhimurium, TA100 and especially TA 98 at concentrations of ≥2 μg/test; in contrast, Na methotrexate (II Na salt) [7413-34-5] did not induce mutagenesis in both strains. Similar observations were made when I and II were tested on human leukocytes by sister chromatid exchanges (SCE); I (10 μg/mL) stimulated SCE frequency, whereas II did not cause significant change in the frequency of SCE. The sensitivity of the SCE method was 1500-fold more sensitive than the other method in testing the mutagenicity of these drugs. In the experiment, the researchers used many compounds, for example, Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5Related Products of 7413-34-5).
Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Related Products of 7413-34-5
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics