Synthesis of chidamide, a new histone deacetylase (HDAC) inhibitor was written by Yin, Zi-hui;Wu, Zhong-wen;Lan, YU-kun;Liao, Chen-zhong;Shan, Song;Li, Zhi-liang;Ning, Zhi-qiang;Lu, Xian-ping;Li, Zhi-bin. And the article was included in Zhongguo Xinyao Zazhi in 2004.Product Details of 119023-25-5 This article mentions the following:
Objective: To synthesize chidamide {N-(2-amino-5-fluorophenyl)-4-[N-(pyridin-3-ylacryloyl)aminomethyl]benzamide}, a new histone deacetylase (HDAC) inhibitor. Methods: 3-Pyridineacrylic acid was prepared from 3-pyridine carboxaldehyde by Knoevenagel reaction, which was converted to the title compound by 2 steps of acetylation in the presence of N,N’-carbonyldiimidazole. Results: Chidamide was synthesized in a total yield of 29%. Conclusion: A gentle and easily controlled process for synthesis of chidamide is worked out. In the experiment, the researchers used many compounds, for example, 2-Amino-4-fluorobenzamide (cas: 119023-25-5Product Details of 119023-25-5).
2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Product Details of 119023-25-5
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics