Copper porphyrin-catalyzed C(sp2)-O bond construction via coupling phenols with formamides was written by Yang, Shuang;Chen, Xiao-Yan;Xiong, Ming-Feng;Zhang, Hao;Shi, Lei;Lin, Dong-Zi;Liu, Hai-Yang. And the article was included in Journal of the Chinese Chemical Society (Weinheim, Germany) in 2021.SDS of cas: 19311-91-2 This article mentions the following:
Copper porphyrin-catalyzed construction of C(sp2)-O bond via coupling formamides with phenols was achieved firstly. A broad range of substrates afforded various carbamates R1R2NC(O)OR [R1 = 4-FC6H4, 3-CHOC6H4, 2-F3CC6H4, etc.; R1 = Me, Et; R2 = Me, Et; R1R2 = CH2CH2OCH2CH2] in moderate to good yields with good functional group tolerance at low catalyst loading. Intermol. competing kinetic isotope effect experiment indicated that the generation of formamide radical was the rate-determining step of current cross-dehydrogenative coupling (CDC) reaction. The research extended the application of metalloporphyrin in CDC reaction. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2SDS of cas: 19311-91-2).
N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.SDS of cas: 19311-91-2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics