Conformationally locked cis-1,2-diaminocyclohexane-based chiral ligands for asymmetric catalysis was written by van Beek, Carim;Samoshin, Vyacheslav V.. And the article was included in Tetrahedron Letters in 2022.SDS of cas: 2387-23-7 This article mentions the following:
An efficient synthesis for a new conformationally locked chiral cis-1,2-diaminocyclohexane scaffold was developed. The conformational lock allows for convenient sym. derivatization of the amino groups through the reductive amination strategy. A series of optically pure chiral ligands I [R = Bn, 2-HOC6H4CH2, 2-MeOC6H4CH2] based on the cis-DACH scaffold was generated to demonstrate a proof-of-concept for these ligands as chiral catalysts in the asym. Henry reaction. Excellent yields with moderate enantioselectivity were demonstrated at room temperature, with an increase in enantioselectivity at lower temperatures, showing the potential of this new type of cis-DACH ligand. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7SDS of cas: 2387-23-7).
1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.SDS of cas: 2387-23-7
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics