Dealkenylative Alkynylation Using Catalytic FeII and Vitamin C was written by Swain, Manisha;Bunnell, Thomas B.;Kim, Jacob;Kwon, Ohyun. And the article was included in Journal of the American Chemical Society in 2022.Safety of 1,3-Dicyclohexylurea This article mentions the following:
In this paper, synthesis of alkyl-tethered alkynes, e.g. I through ozone-mediated and FeII-catalyzed dealkenylative alkynylation of unactivated alkenes in presence of alkynyl sulfones was reported. This one-pot reaction, which employed a combination of a catalytic FeII salt and L-ascorbic acid, proceeded under mild conditions with good efficiency, high stereoselectivity, and broad functional group compatibility. In contrast to previous FeII-mediated reductive fragmentation of α-methoxyhydroperoxides, FeII-catalyzed process was devised through a thorough kinetic anal. of multiple competing radical (redox) pathways. The potential of this dealkenylative alkynylation through multiple post-synthetic transformations and late-stage diversifications of complex mols., including natural products and pharmaceuticals was highlighted. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Safety of 1,3-Dicyclohexylurea).
1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Safety of 1,3-Dicyclohexylurea
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics