Sun, Jiali et al. published their research in Chinese Journal of Chemistry in 2020 | CAS: 53902-12-8

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Application of 53902-12-8

Predicting the Loading Capability of mPEG-PDLLA to Hydrophobic Drugs Using Solubility Parameters was written by Sun, Jiali;Wei, Qi;Shen, Na;Tang, Zhaohui;Chen, Xuesi. And the article was included in Chinese Journal of Chemistry in 2020.Application of 53902-12-8 This article mentions the following:

Summary of main observation and conclusion : Phys. encapsulation of drugs into polymer micelles is a common method of loading hydrophobic drugs. Methoxy polyethylene glycol-poly(D,L-lactide) (mPEG-PDLLA) is one of the most commonly used drug carrier. At present, whether a carrier is suitable for the loading of a certain drug is determined by drug loading experiments This process costs a lot of time. Therefore, an efficient predicting method to avoid time-consuming tests is critical In this study, we prepared mPEG5k-PDLLA5k and used it to load a series of drugs. Three parameters were used to test the miscibility of mPEG5k-PDLLA5k with drugs, including absolute difference in Hildebrand solubility parameters (|Δδ|), Flory-Huggins interaction parameter (Χ) and the distance (D value) calculated from the two-dimensional solubility parameters. We found the two-dimensional solubility parameters obtained from JB2013 group contribution (GC) method was useful. By comparing the drug loading content (DLC) with the D value, we found that when the D value was less than 5.0 (MJ/m3)1/2, the miscibility of drug and mPEG5k-PDLLA5k was good and drug loading capability was high; when the D value was more than 8.0 (MJ/m3)1/2, the drug was barely loaded. Thus, this work provided a rationale to qual. predict the loading capability of mPEG5k-PDLLA5k for hydrophobic drugs. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Application of 53902-12-8).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Application of 53902-12-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics