Regioselective Synthesis of Enones via a Titanium-Promoted Coupling of Unsymmetrical Alkynes with Weinreb Amides was written by Silwal, Sajan;Rahaim, Ronald J.. And the article was included in Journal of Organic Chemistry in 2014.Application of 116332-61-7 This article mentions the following:
A modular titanium-promoted coupling of unsym. internal alkynes with Weinreb amides is described. The coupling reaction takes place at room temperature and affords E-trisubstituted enones in moderate to good yields with high levels of regioselectivity. E.g., in presence of Ti(OiPr)4 and i-PrMgCl in Et2O at room temperature, coupling of 1-phenyl-1-propyne and 4-FC6H4CONMeOMe gave 60% (E)-I. The system shows moderate chemoselectivity. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Application of 116332-61-7).
N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Application of 116332-61-7
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics