Protective effects of tranilast on experimental colitis in rats was written by Seto, Yoshiki;Kato, Kouki;Tsukada, Ryota;Suzuki, Hiroki;Kaneko, Yuuki;Kojo, Yoshiki;Sato, Hideyuki;Onoue, Satomi. And the article was included in Biomedicine & Pharmacotherapy in 2017.Product Details of 53902-12-8 This article mentions the following:
The present study aimed to verify the efficacy of tranilast (TL) for treating inflammatory bowel disease (IBD) with the use of an exptl. colitis model. The exptl. colitis model was prepared by intrarectal instillation of 2,4,6-trinitrobenzenesulfonic acid (TNBS; 40 mg/kg) dissolved in water containing 25% ethanol. The pharmacol. effects of TL after repeated oral administration were evaluated by biomarker and histol. analyses, and the pharmacokinetic behavior of TL was also examined after single oral administration. The intrarectal instillation of TNBS solution caused colitis, as evidenced by ca. 2.2-, 5-, and 3-fold increases in myeloperoxidase (MPO) activity, infiltrated cell numbers, and the thickness of the submucosa in the colon, resp. However, orally-taken TL (10 mg/kg, twice a day for 9 days) led to a 92% reduction in the increase of the MPO level by TNBS enema, and cellular infiltration and thickened submucosa in the exptl. colitis model tended to also be suppressed by repeated oral administration of TL. The oral bioavailability of TL in TNBS-treated rats was calculated to be as low as ca. 6.5%, and the poor oral absorption of TL may be a limitation of the treatment for IBD. TL could attenuate TNBS-induced colitis on the basis of the obtained results, and the anti-inflammatory effects would have clin. relevance to the therapeutic outcomes of TL in IBD patients. Although further improvement in the oral bioavailability of TL might be required for better pharmacol. outcomes, TL would be an efficacious agent for treating IBD. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Product Details of 53902-12-8).
2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Product Details of 53902-12-8
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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics