The synthesis of proximal-benzolumazine, proximal-benzoxanthine, proximal-benzotheophylline and proximal-benzocaffeine was written by Schneller, Stewart W.;Christ, William J.. And the article was included in Journal of Heterocyclic Chemistry in 1981.Application of 54166-95-9 This article mentions the following:
Title compounds I and II (R = R1 = H; R = R1 = Me; R = Me, R1 = H) were prepared by commencing with 2,6-Cl(H2H)C6H3CONH2 and proceeding via a variety of 5,6-disubstituted 2,4(1H,3H)-quinazolinediones. Methylation of II (R = Me, R1 = H) gave III and II (R = R1 = Me) in a ratio of 4:1. In the experiment, the researchers used many compounds, for example, 6-Chloro-2-aminobenzamide (cas: 54166-95-9Application of 54166-95-9).
6-Chloro-2-aminobenzamide (cas: 54166-95-9) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Application of 54166-95-9
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics