Antipyretic activity of new salicylate and gentisate derivatives was written by Preziosi, P.. And the article was included in Bollettino – Societa Italiana di Biologia Sperimentale in 1953.Synthetic Route of C11H15NO2 This article mentions the following:
Salicylic hydrazide, acetylsalicylic hydrazide, N,N-diethylsalicylamide, gentisamide, ο-ethoxybenzamide, salicylamide, diacetylgentisic acid, and ο-(diethylaminoethoxy)benzamide were tested for antipyretic activity on rabbits. Fever was induced by intravenous injection of pyrogen and the material being tested was introduced peritoneally. Results show decreasing activity of the materials in the order listed. All of the compounds with the exception of the last 2 produced a temperature drop within 3-4 hours. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Synthetic Route of C11H15NO2).
N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Synthetic Route of C11H15NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics