Synthesis of Difluoromethyl Ketones from Weinreb Amides, and Tandem Addition/Cyclization of o-Alkynylaryl Weinreb Amides was written by Phetcharawetch, Jongkonporn;Betterley, Nolan M.;Soorukram, Darunee;Pohmakotr, Manat;Reutrakul, Vichai;Kuhakarn, Chutima. And the article was included in European Journal of Organic Chemistry in 2017.Related Products of 192436-83-2 This article mentions the following:
[Difluoro(phenylsulfanyl)methyl]trimethylsilane (PhSCF2SiMe3) underwent a fluoride-induced nucleophilic addition to the carbonyl group of Weinreb amides to provide the corresponding difluoro(phenylsulfanyl)methyl ketones I (R = Ph, 3-MeOC6H4, 2-BrC6H4, cyclohexyl, n-heptyl, etc.). These were converted into difluoromethyl ketones through selective reductive cleavage of the phenylsulfanyl group. The reaction of o-alkynyl Weinreb amides derived from benzoic acid derivatives resulted in the formation of cyclized products II (R = Ph, 4-MeOC6H4, 4-BrC6H4, etc.) through a 5-exo-dig cyclization. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Related Products of 192436-83-2).
4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Related Products of 192436-83-2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics