Graphene Oxide: A Metal-Free Carbocatalyst for the Synthesis of Diverse Amides under Solvent-Free Conditions was written by Patel, Khushbu P.;Gayakwad, Eknath M.;Patil, Vilas V.;Shankarling, Ganapati S.. And the article was included in Advanced Synthesis & Catalysis in 2019.HPLC of Formula: 2387-23-7 This article mentions the following:
An environment-friendly, inexpensive, carbocatalyst, graphene oxide (GO) which promoted efficient, metal-free transamidation of various carboxamides RC(O)NH2 (R = Ph, pyridin-2-yl, H, Me, etc.) with aliphatic, cyclic, and aromatic amines NH(R1)(R2) [R1 = H, Ph; R2 = n-Bu, Ph, cyclohexyl, pyridin-2-yl, etc.; R1R2 = -(CH2)4-, -CH2CH2OCH2CH2-] and 2-aminothiophenol is demonstrated. The protocol is equally applicable to phthalimides such as 1H-isoindole-1,3(2H)-dione, 5-methyl-1H-isoindole-1,3(2H)-dione, ureas R3NHC(O)NH2 (R3 = H, Ph), and thioamide determining its adaptability. The oxygenated functionalities such as carbonyl (-C=O), epoxy (-O-), carboxyl (-COOH) and hydroxyl (-OH), present on graphene oxide surface impart acidic properties to the catalyst. The graphene oxide being heterogeneous in nature, work efficiently under solvent-free reaction conditions providing desired products RC(O)N(R1)(R2), I, R1NHC(O)NHR2 in good to excellent yields. The one-pot synthesis of 2,3-dihydro-5H-benzo[b]-1,4-thiazepin-4-one moiety by GO catalyzed Aza Michael addition followed by intramol. transamidation is also described. A plausible reaction mechanistic pathway involving H-bonding is discussed. The graphene oxide can be recycled and reused up to five cycles without much loss in catalytic activity. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7HPLC of Formula: 2387-23-7).
1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.HPLC of Formula: 2387-23-7
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics