An efficient synthesis of 3-cyano-1(3H)-isobenzofuranones was written by Okazaki, Kousuke;Nomura, Keiichi;Yoshii, Eiichi. And the article was included in Synthetic Communications in 1987.Formula: C11H15NO2 This article mentions the following:
Salicylamides I (R1 = H, OMe, OCH2OMe; R2 = H, OMe, F; R3 = H, OMe; R4 = H, OMe, OCH2OMe, F) were converted to phthalides II in two steps. I were treated with MeSiCN, KCN, and 18-crown-6 to yield cyanohydrin derivatives III, and the latter were kept in HOAc to give II. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Formula: C11H15NO2).
N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Formula: C11H15NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics