Structurally Diverse Synthesis of Five-, Six- and Seven-membered Benzosultams through Electrochemical Cyclization was written by Liu, Aiyun;Guo, Tiantian;Zhang, Shuangshuang;Yang, Han;Zhang, Qi;Chai, Yonghai;Zhang, Shengyong. And the article was included in Organic Letters in 2021.Quality Control of N-Isopropylbenzenesulfonamide This article mentions the following:
A metal- and oxidant-free approach to structurally diverse synthesis of benzosultams I (R1 = i-Pr, t-Bu, Me; R2 = H, 8-Ph, 7,9-di-Me, 9-F, etc.), II (R3 = H, Me) and III (R4 = H, 4-Cl, 5-Me, 6-Me, etc.) from aryl sulfonamides R1C6H3S(O)2R5 (R5 = H, 4-Me, 3-Cl, 6-Cl, etc.) through an electrochem. cyclization was developed. By varying the ortho-substituent on aryl sulfonamides, five-, six-, and seven-membered benzosultams I, II and III were efficiently assembled in an atom- and resource-economic manner. The generality of the process is demonstrated by the formation of five to seven-membered cyclic products from substrates bearing substituents R1C6H3S(O)2R5 with different electronic effects and steric hindrance. In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5Quality Control of N-Isopropylbenzenesulfonamide).
N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Quality Control of N-Isopropylbenzenesulfonamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics