Weinreb Amide Directed Versatile C-H Bond Functionalization under (η5-Pentamethylcyclopentadienyl)cobalt(III) Catalysis was written by Kawai, Kentaro;Bunno, Youka;Yoshino, Tatsuhiko;Matsunaga, Shigeki. And the article was included in Chemistry – A European Journal in 2018.Safety of 4-Bromo-N-methoxy-N-methylbenzamide This article mentions the following:
The (η5-pentamethylcyclopentadienyl)cobalt(III) (Cp*CoIII)-catalyzed C-H bond functionalization of aromatic, heteroaromatic and α,β-unsaturated Weinreb amides was explored. The C-H allylation using allyl carbonate and a perfluoroalkene/oxidative alkenylation with Et acrylate/iodination using N-iodosuccinimide and amidation with dioxazolones were catalyzed by Cp*Co(CO)I2 in presence of cationic silver salt and silver acetate to afford various synthetically useful building blocks like RC(O)N(Me)(OMe) [R = 2-H2C=CHCH2C6H4, MeC=CHCH=CHCO2Et, 2-I-C6H4, etc.]. Mechanistic studies of C-H allylation disclosed that the C-H activation step was rate determining and virtually irreversible. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Safety of 4-Bromo-N-methoxy-N-methylbenzamide).
4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Safety of 4-Bromo-N-methoxy-N-methylbenzamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics