Sequential One-pot Method for the Synthesis of 4-(Hydroxymethyl)oxazoles and their Application in Phosphonates Synthesis was written by Kajol, Km;Ramesh, Chintakunta. And the article was included in Asian Journal of Organic Chemistry in 2021.SDS of cas: 2670-38-4 This article mentions the following:
A sequential one-pot method for the synthesis of 4-(hydroxymethyl)oxazoles from readily available benzamides was developed. Various substituted benzamides well-tolerated and furnished 4-(hydroxymethyl)oxazoles in moderate to good yields under the present reaction conditions. In order to demonstrate the usefulness of the present methodol., the resulting 4-(hydroxymethyl)oxazoles were successfully transformed into its corresponding phosphonates under Michaelis-Arbuzov reaction conditions. This methodol. featured a broad substrate scope, step economy, ease of execution, and scalability. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4SDS of cas: 2670-38-4).
3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.SDS of cas: 2670-38-4
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics