Enantioselective sulfoxide-directed preparation of 1,2-diols from oxalic compounds: formal synthesis of the 10-membered lactone core of ascidiatrienolides and didemnilactones was written by Izzo, Irene;Crumbie, Robin;Solladie, Guy;Hanquet, Gilles. And the article was included in Tetrahedron: Asymmetry in 2005.Synthetic Route of C6H12N2O4 This article mentions the following:
The synthesis of diene I, which is available in both possible absolute configurations is described. This diene constitutes the key intermediate of a previous synthesis of the 10-membered lactone core of the marine natural products ascidiatrienolides and didemnilactones. Intermediate I is available via two successive highly diastereoselective sulfoxide-directed reductions of oxalic diamide II. In the experiment, the researchers used many compounds, for example, N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1Synthetic Route of C6H12N2O4).
N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Synthetic Route of C6H12N2O4
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics