Binding of drugs to liposome-entrapped macromolecules prevents diffusion of drugs from liposomes in vitro and in vivo was written by Gregoriadis, Gregory;Davisson, Pamela J.;Scott, Susan. And the article was included in Biochemical Society Transactions in 1977.Computed Properties of C20H20N8Na2O5 This article mentions the following:
A technique is described to delay the diffusion of small-mol.-weight drugs from liposomes by binding the drugs to liposome-associated macromols. Melphalan [148-82-3] was bound to Na polyglutamate [26247-79-0] and incorporated into egg lecithin liposomes; after i.v. injection into rats, liposomal polyglutamate-bound melphalan was eliminated from the blood plasma at a much slower rate than free melphalan. Similar results were obtained for Na methotrexate [7413-34-5] bound to polyglutamate in egg lecithin liposomes, and for daunomycin [20830-81-3] bound to calf thymus DNA in egg lecithin liposomes. In the experiment, the researchers used many compounds, for example, Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5Computed Properties of C20H20N8Na2O5).
Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Computed Properties of C20H20N8Na2O5
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics