Analysis of procarbazine and metabolites by gas chromatography-mass spectrometry was written by Gorsen, Robert M.;Weiss, A. J.;Manthei, R. W.. And the article was included in Journal of Chromatography, Biomedical Applications in 1980.Product Details of 13255-50-0 This article mentions the following:
Procarbazine-HCl (I) [366-70-1], and several metabolites, and an internal standard were analyzed by gas chromatog.-mass spectrometry on a 3% OV-1 column. Procarbazine and 4 metabolites were derivatized with acetic anhydride. A sensitive, specific and quant. assay was established by selected ion monitoring using a synthetic analog of the drug as an internal standard The limits of detection were approx. 1 ng/mL of plasma while the limits of quantitation were 10 ng/mL of plasma. Studies on the degradation of procarbazine-HCl in 0.05 M phosphate buffer (pH 7.4) were compared to in vivo studies. At 1 h after incubation of procarbazine-HCl in buffer, the azo and aldehyde metabolites were detected in the highest concentrations representing 27.2% and 20.3% of total drug and metabolites. In the in vivo studies, analyses of rat plasmas indicated that 1 h after an oral dose of procarbazine-HCl the aldehyde metabolite [13255-50-0] represented 72% of the total drug and metabolites, and that relatively little of the azo metabolite was present. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Product Details of 13255-50-0).
4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Product Details of 13255-50-0
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics