Synthesis of 3,4-difluorobenzonitrile was written by Chen, Qiang;Zhang, Shaohui;Cheng, Zhiming. And the article was included in Jingxi Huagong Zhongjianti in 2006.Recommanded Product: 2670-38-4 This article mentions the following:
3,4-Difluorobenzonitrile is an important intermediate of selective herbicide, cyhalofop Bu. 3,4-Difluorobenzonitrile was synthesized by 3,4-dichlorobenzoyl chloride through amidation, dehydration and fluorination. The yield was 39.8%, and the content was 99.0%. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Recommanded Product: 2670-38-4).
3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 2670-38-4
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics