I2-Catalyzed cross dehydrogenative coupling: rapid access to benzoxazinones and quinazolinones was written by Chen, Kaili;Gao, Biao;Shang, Yanguo;Du, Jianyao;Gu, Qinlan;Wang, Jinxin. And the article was included in Organic & Biomolecular Chemistry in 2017.Computed Properties of C11H15NO2 This article mentions the following:
An efficient and applicable I2-catalyzed intramol. dehydrogenative C-O/C-N coupling reaction via activating the C-H bond adjacent to the N atom has been developed to provide dozens of substituted benzoxazinones I (R1 = H, 8-OMe, 6-F, etc.; R2 = Me, Et, Bn, etc.; R3 = C6H5, 4-H3CC6H4, 4-FC6H4, etc.; X = O, S) (31 examples) and quinazolinones, e.g. II (5 examples) in good to excellent yields (up to 98%). This one-pot methodol. has significant advantages, including a metal-free process, broad substrate scope, high atom economy, and simple operation. This strategy goes through an iminium intermediate followed by nucleophilic attack to provide the desired products. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Computed Properties of C11H15NO2).
N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Computed Properties of C11H15NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics