The analgesic properties of some substituted salicylamide derivatives was written by Carron, M.;Tabart, J.;Jullien, Mrs.. And the article was included in Therapie in 1952.Related Products of 19311-91-2 This article mentions the following:
Derivatives of salicylamide (I) were prepared; they had general formulas C6H4OH.CONRR’ or C6H4CONH2. OR”. Their lethal doses (per os) and analgesic effects were determined by the Armour and Smith method (J. Pharm. Exptl. Therap. 72, 74, 1941). Introduction of hydrosol. groups, methoxylation, and acetylation of the phenolic function lowered the analgesic power; ethoxylation of the same increased it. Substitution of amide H by alkyls activated the analgesic effect from Et to iso-Pr, but Me and Bu derivatives had low activities. Hydrosol. functions introduced on the amide did not modify the effect of the products. Joining 2 I mols by a C3 chain increased its effect, but a C1 or C2 linkage lowered the activity of the compounds Min. analgesic doses and lethal doses of the most active derivatives compared with acetylsalicylic acid (II) were: I 0.3, 0.6; N-diethyl-I 0.15, 0.85; o-ethoxybenzamide 0.2, 0.7; o-acetylsalicylureide 0.2, 0.3; methylol-I 0.24, 0.85; N-isopropyl-I 0.25, 0.65; propylenebis-I 0.26, 0.95; and II 0.4, 0.83 g./kg. weight of mice. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Related Products of 19311-91-2).
N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Related Products of 19311-91-2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics