N,N’-Dicyclohexyl-N-(phthaloylglycyl)urea was written by Bernes, Sylvain;Hernandez-Linares, Maria Guadalupe. And the article was included in IUCrData in 2021.Computed Properties of C13H24N2O This article mentions the following:
The mol. structure of the title compound {systematic name: 1,3-dicyclohexyl-1-[2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)acetyl]urea}, C23H29N3O4, derived from N,N’-dicyclohexylurea, shows that the tertiary N atom substituted by a cyclohexyl and phthaloylglycyl groups adopts a perfectly planar geometry (bond-angle sum = 360.0°). In the same way as for N,N’-dicyclohexylurea, the extended structure of the title compound features N-H···O hydrogen bonds, which generate chains of mols. running in the [001] direction. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Computed Properties of C13H24N2O).
1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Computed Properties of C13H24N2O
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics