Hypervalent Iodine Catalyzed Hofmann Rearrangement of Carboxamides Using Oxone as Terminal Oxidant was written by Yoshimura, Akira;Middleton, Kyle R.;Luedtke, Matthew W.;Zhu, Chenjie;Zhdankin, Viktor V.. And the article was included in Journal of Organic Chemistry in 2012.Related Products of 10268-06-1 This article mentions the following:
Hofmann rearrangement of carboxamides to carbamates using Oxone as an oxidant can be efficiently catalyzed by iodobenzene. This reaction involves hypervalent iodine species generated in situ from catalytic amount of PhI and Oxone in the presence of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) in aqueous methanol solutions Under these conditions, Hofmann rearrangement of various carboxamides affords corresponding carbamates in high yields. In the experiment, the researchers used many compounds, for example, 2-(2-Chlorophenyl)acetamide (cas: 10268-06-1Related Products of 10268-06-1).
2-(2-Chlorophenyl)acetamide (cas: 10268-06-1) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Related Products of 10268-06-1
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics