Nitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles was written by Liu, Jianzhong;Zhang, Cheng;Zhang, Ziyao;Wen, Xiaojin;Dou, Xiaodong;Wei, Jialiang;Qiu, Xu;Song, Song;Jiao, Ning. And the article was included in Science (Washington, DC, United States) in 2020.Reference of 2670-38-4 This article mentions the following:
The Schmidt reaction has been an efficient and widely used synthetic approach to amides and nitriles since its discovery in 1923. However, its application often entails the use of volatile, potentially explosive, and highly toxic azide reagents. Here, we report a sequence whereby triflic anhydride and formic and acetic acids activate the bulk chem. nitromethane to serve as a nitrogen donor in place of azides in Schmidt-like reactions. This protocol further expands the substrate scope to alkynes and simple alkyl benzenes for the preparation of amides and nitriles. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Reference of 2670-38-4).
3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Reference of 2670-38-4
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics