Copper-catalyzed and additive free decarboxylative trifluoromethylation of aromatic and heteroaromatic iodides was written by Johansen, Martin B.;Lindhardt, Anders T.. And the article was included in Organic & Biomolecular Chemistry in 2020.Category: amides-buliding-blocks This article mentions the following:
A copper-catalyzed decarboxylative trifluoromethylation of (hetero)aromatic iodides RI (R = 4-cyanophenyl, naphthalen-1-yl, 1-benzyl-1H-pyrazol-4-yl, etc.) has been developed. Importantly, this new copper-catalyzed reaction operates in the absence of any ligands and metal additives. The protocol shows good functional group tolerance and is compatible with heteroaromatic systems. The reaction proved scalable to a 15 mmol scale with increased yield. Finally, late-stage installation of the trifluoromethyl functionality afforded the 2,2,2-trifluoro-N-(3-(4-iodophenoxy)-3-phenylpropyl)-N-methylacetamide variant of the antidepressant agent, Prozac, demonstrating the applicability of the developed method. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Category: amides-buliding-blocks).
N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics