Mechanochemical Synthesis of Primary Amides was written by Gomez-Carpintero, Jorge;Sanchez, J. Domingo;Gonzalez, J. Francisco;Menendez, J. Carlos. And the article was included in Journal of Organic Chemistry in 2021.Electric Literature of C6H13NO3 This article mentions the following:
Ball milling of aromatic, heteroaromatic, vinylic, and aliphatic esters RCOOEt (R = 3-fluorophenyl, 1,3-diethoxy-1,3-dioxopropan-2-yl, thiophen-2-yl, etc.) and 2-chromanone with ethanol and calcium nitride afforded the corresponding primary amides RC(O)NH2in a transformation that was compatible with a variety of functional groups and maintained the integrity of a stereocenter α to carbonyl. This methodol. was applied to α-amino esters (S)-H2NCH(CH2R1)C(O)OEt [R1 = Ph, (methylsulfanyl)methyl] and N-Boc dipeptide esters (S)-(CH3)3COC(O)NHCH(CH2R2)C(O)NHCH2C(O)OEt (R2 = H, Ph, 1H-indol-3-yl) and also to the synthesis of rufinamide, an antiepileptic drug. In the experiment, the researchers used many compounds, for example, 2,2-Diethoxyacetamide (cas: 61189-99-9Electric Literature of C6H13NO3).
2,2-Diethoxyacetamide (cas: 61189-99-9) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Electric Literature of C6H13NO3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics