The effect of methotrexate on experimental salivary gland neoplasia in rats was written by Shklar, G.;Sonis, S. T.. And the article was included in Archives of Oral Biology in 1975.Reference of 7413-34-5 This article mentions the following:
Na methotrexate (I) [7413-34-5] (0.1 or 1.0 mg, s.c., twice weekly) accelerated carcinogenesis induced by implantation of 9,10-dimethyl-1,2-benzanthracene (II) pellets into the right submandibular gland of rats. After 12 weeks the carcinomas in I and II-treated rats were considerably larger than those in II-treated animals and there was greater invasiveness into the glandular tissue. In the experiment, the researchers used many compounds, for example, Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5Reference of 7413-34-5).
Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Reference of 7413-34-5
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics