Gorshkova, O. P. et al. published their research in Journal of Evolutionary Biochemistry and Physiology in 2022 | CAS: 10238-21-8

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Quality Control of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide

Age-Related Changes in the Functional Activity of ATP-Sensitive Potassium Channels in Rat Pial Arteries was written by Gorshkova, O. P.. And the article was included in Journal of Evolutionary Biochemistry and Physiology in 2022.Quality Control of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide This article mentions the following:

Age-related changes in the contribution of ATP-sensitive potassium channels (KATP) to basal tone and acetylcholine (ACh)-mediated dilation of pial arterial vessels were studied in Wistar rats aged 4 and 18 mo using intravital microphotog. A change in the contribution of KATP channels to the maintenance of basal tone was assessed by the change in the number of vessels constricted in response to a KATP channel blocker glibenclamide (10 μM). A change in the contribution of KATP channels to vasodilation was assessed by comparing the number and degree of arterial dilation in response to ACh (10-7 M, 5 min) before and after glibenclamide application. It was found that aging is accompanied by a decrease in the contribution of KATP channels to basal tone of pial arteries. Moreover, the functional activity of KATP channels and their contribution to vasodilation decreases with age, and in 18-mo-old rats they are practically not involved in the dilatory response to ACh. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Quality Control of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Quality Control of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics