A facile synthesis of 2,3-disubstituted furo[2,3-b]pyridines was written by Beutner, Gregory L.;Kuethe, Jeffrey T.;Yasuda, Nobuyoshi. And the article was included in Tetrahedron Letters in 2009.Related Products of 116332-61-7 This article mentions the following:
In a three-step sequence starting from readily available starting materials, 2,3-carbon disubstituted furo[2,3-b]pyridines can be accessed in good yields and purity. Furo[2,3-b]pyridines bearing ester, amide and ketone groups at the 2-position can be prepared with a variety of aryl and alkyl groups at the 3-position. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Related Products of 116332-61-7).
N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Related Products of 116332-61-7
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics