A Strategy for Amide to β-Oxo Ester Transformation via N-Alkenoxypyridinium Salts as the Activator and H2O as the Nucleophile was written by Wu, Nan;Li, Chuang;Mi, Jiajia;Zheng, Yan;Xu, Zhou. And the article was included in Organic Letters in 2020.Recommanded Product: N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide This article mentions the following:
N-Alkenoxypyridinium salts were found to be highly active electrophilic reagents that could be used to activate the C-N bond of amides. Both aromatic amides and aliphatic amides could be transformed into the corresponding β-oxo esters with good yields via the combined use of N-alkenoxypyridinium salts and water. The methodol. proceeds under mild reaction conditions and is tolerant of various functional groups in both reaction partners. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Recommanded Product: N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide).
N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Recommanded Product: N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics